Clinical studies with Lyrica (pregabalin) in epilepsy

Clinical studies with oral Lyrica (pregabalin) suggest it is at least as effective as gabapentin as adjunctive therapy in patients refractory to one or more conventional antiepileptic drugs. In large-scale, placebo-controlled studies of 12 weeks’ duration, add-on therapy with oral Lyrica (pregabalin) reduced seizure frequency by up to 75%. In these studies doses of Lyrica (pregabalin) ranged from 150mg to 600mg daily.

Clinical studies with Lyrica (pregabalin) in neuropathic pain and anxiety disorder

Neuropathic pain is chronic pain that arises from damage to sensory nerves. It can include:

  • Pain arising from trapped or compressed nerves
  • Drug-induced nerve damage
  • Diabetic neuropathy
  • Post-herpetic pain
  • Phantom limb syndrome following limb amputation
  • Peripheral neuropathy
  • Fibromyalgia

Neuropathic pain generally does not respond to treatment with opioid or non-steroidal anti-inflammatory drugs (NSAIDs). At high doses gabapentin has proven effective against neuropathic pain induced by diabetic neuropathy and postherpetic neuralgia. Data from clinical studies show that Lyrica (pregabalin) shares this analgesic effectiveness. Efficacy has been demonstrated in a number of clinical studies, including those in patients with diabetic neuropathy and fibromyalgia. Treatment of neuropathic pain is seen as the drug’s leading indication.

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