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Attribute |
Details |
Generic Name |
Pregabalin |
Brand Names |
Lyrica, among others |
Drug Class |
Anticonvulsant, Neuropathic Pain Agent |
FDA Approved |
Yes, for various conditions including neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, fibromyalgia, and partial onset seizures in adults. |
Mechanism of Action |
Binds to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system, which diminishes the release of several neurotransmitters, including glutamate, norepinephrine, and substance P, leading to decreased pain and seizures. |
Common Dosages |
Available in capsule form and oral solution. Common dosages include 50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 225 mg, and 300 mg capsules. |
Side Effects |
May include dizziness, sleepiness, dry mouth, swelling, blurred vision, weight gain, and difficulty concentrating. Serious side effects can include allergic reactions, suicidal thoughts or behaviors, and angioedema. |
Interactions |
Can interact with certain drugs such as opioids, benzodiazepines, and alcohol, increasing the risk of respiratory depression and sedation. |
Pregnancy Category |
C (Risk not ruled out). Animal studies have shown potential risks, but there are no sufficient and well-controlled studies in pregnant women. |
Usage Tips |
Start with a low dose and gradually increase to minimize side effects. Do not abruptly stop taking Pregabalin to avoid withdrawal symptoms. Consult with a healthcare provider for personalized advice. |
This table provides a summary of essential information about Pregabalin, but always consult healthcare providers for personalized medical advice and information.